Itrakonazol, ketokonazol i u manjoj meri flukonazol i vorikonazol su snažni inhibitori izoenzima CYP3A4 citohroma P450 i mogu povećati koncentraciju benzodiazepina u plazmi.
Fluoksetin inhibira metabolizam diazepama preko CYP2C19 i ostalih metaboličkih puteva, što dovodi do povećanja koncentracije i smanjenja klirensa diazepama. Pojačano je dejstvo diazepama. Potreban je pojačan nadzor pri istovremenoj primeni.
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Usporen metabolizam diazepama dovodi do produženja poluvremena eliminacije i povećanja koncentracije diazepama u plazmi. Usporena je eliminacija N-demetil metabolita diazepama, što može značajno pojačati sedativni efekat. Povećan je rizik od inhibicije CNS, npr. sedacije.
There won't be any ample experiments in Females for determining infant danger when making use of this medication all through breastfeeding. Weigh the potential Rewards from the potential hazards right before having this medication when breastfeeding.
Diazepam je detektovan u majčinom mleku. Ukoliko je moguće, primenu diazepama tokom perioda dojenja treba izbegavati.
This drugs need to feature a Medication Manual and individual Directions. Examine and Adhere to the Guidance diligently. Question your physician In case you have any thoughts.
Upotreba diazepama kod pacijenata sa insuficijencijom jetre može dovesti do kome, pa je zato potrebno smanjiti dozu ili razmotriti primenu drugog leka. Kod pacijenata sa teškom insuficijencijom bubrega takođe treba smanjiti dozu.
eight check here ug/mL. Outcomes point out that there is no sizeable distinction between parotid saliva and blended saliva concentrations about a period of eight hr following one oral dose of diazepam Which look of diazepam in saliva may perhaps supply an alternate, noninvasive means of determining plasma diazepam concentrations.
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Moguća je pojava pospanosti, smanjenja psihomotornih performansi i slabljenje pamćenja. Stoga se preporučuje primena benzodiazepina koji se ne metabolišu oksidativnim metaboličkim putevima.
Postoje indikacije kod kojih, u slučaju benzodiazepina kratkog dejstva, simptomi obustave mogu da se manifestuju unutar doznog intervala, naročito kada su doze velike.
Benzodiazepini click here se ne preporučuju kao početna terapija kod pacijenata sa psihotičnim poremećajem.
In early pregnancy, codeine continues to be linked to some difficulties during the unborn infant. If you're taking codeine at the conclusion of pregnancy there is a risk that your newborn may perhaps get withdrawal signs after start. The baby could also get respiratory complications.